首页|Metal organic frameworks as advance d adsorb ent materials for separation and analysis of complex samples

Metal organic frameworks as advance d adsorb ent materials for separation and analysis of complex samples

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  • NSTL
  • Elsevier
Sample pre-treatment is of great significance for study protein phosphorylation and glycosylation. Due to the low concentration and suppression of matrices, the direct detection of phosphoprotein and glycoprotein by mass spectrometry (MS) are still facing many challenges. The demand of efficient and specific enrichment of phosphoprotein and glycoprotein promotes the sample preparation methods based on metal-organic frameworks (MOFs). In this review, recent advances in MOFs-based samples pre-treatment, including the enrichment of protein, endogenous peptides, glycopeptides, phosphopeptides and glycans are summarized and discussed. In addition, the design and synthesis of different types of MOFs according to different enrichment mechanisms and principles are discussed. Furthermore, the potential problems of sample pre-treatment in proteomics is prospected.(c) 2022 Elsevier B.V. All rights reserved.

EnrichmentSample pre-treatmentMetal-organic frameworks (MOFs)ProteomicsHIGHLY EFFICIENT ENRICHMENTSELECTIVE ENRICHMENTDESIGNED SYNTHESISAFFINITY PROBEPROTEIN-PHOSPHORYLATIONGLYCOPROTEOMIC ANALYSISSIMULTANEOUS EXCLUSIONHYDRAZIDE CHEMISTRYFACILE PREPARATIONPHOSPHOPEPTIDES

Wang, Baichun、Yan, Yinghua、Ding, Chuan-Fan

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Ningbo Univ

2022

10.1016/j.chroma.2022.462971

Journal of chromatography

Journal of chromatography

ISSN：0021-9673
年,卷(期)：2022.1671
  • 9
  • 133