Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers
Li, Biyun 1Xiong, Feng 1Yao, Bo 1Du, Qian 1Cao, Jun 1Qu, Jiangang 2Feng, Wei 3Yuan, Huihua1
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作者信息
1. Nantang Univ, Sch Life Sci, Nantang 226019, Jiangsu, Peoples R China
2. Nantong Univ, Sch Text & Clothing, Nantong 226019, Jiangsu, Peoples R China
3. Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
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Abstract
Electrospun poly(l)-lactide (PLLA) ultrafine fibers are a biodegradable and biocompatible scaffold, widely used in tissue engineering applications. Unfortunately, these scaffolds have some limitations related to the absence of bioactivity and antibacterial capacity. In this study, dopamine-functionalized reduced graphene oxide (rGO)/PLLA composite nanofibers were fabricated via electrospinning. The morphology and the physicochemical and biological properties of the composite nanofibers were investigated. The results indicate that incorporating rGO improves the hydrophilic, mechanical, and biocompatibility properties of PLLA nanofibers. Tetracycline hydrochloride (TC)-loaded rGO/PLLA composite nanofibers showed better controlled drug release profiles compared to GO/PLLA and PLLA nanofibrous scaffolds. Drug-loaded nanofibrous scaffolds showed significantly improved antibacterial activity against Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus). Additionally, rGO/PLLA composite nanofibers exhibited enhanced cytocompatibility. Thus, it can be concluded that rGO/PLLA composite nanofibers allow the development of multifunctional scaffolds for use in biomedical applications.
NSTL
Royal Soc Chemistry