首页|Assessment of tryptophan and kynurenine as prognostic markers in patients with SARS-CoV-2
Assessment of tryptophan and kynurenine as prognostic markers in patients with SARS-CoV-2
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NSTL
Elsevier
? 2021 Elsevier B.V.Background: Immune dysregulation and inflammation in patients with SARS-CoV-2 is associated with a poor clinical outcome. We investigated the value of the inflammatory markers tryptophan and kynurenine in predicting the survival outcome of patients with SARS-CoV-2. Methods: The study included 252 inpatients with a SARS-CoV-2 infection hospitalized between August 2020 and April 2021. Two groups were generated based on disease survival (survival group: n = 199; deceased group: n = 53). Plasma concentrations of tryptophan, kynurenine and interleukin-6 (IL-6) were measured on admission. In a subset of patients (n = 105; 81 survivors and 24 deceased) concentrations of tryptophan and kynurenine were checked 7 days after admission. The kynurenine/tryptophan ratio (TRP/KYN ratio) was calculated. Results: On admission, the deceased group showed significantly higher concentrations of kynurenine and a significantly higher KYN/TRP ratio compared to the survival group (p-values < 0.001). Kynurenine and the KYN/TRP ratio significantly correlated with IL-6 (ρ = 0.441 and 0.448, p-values < 0.001). In the survival group, kynurenine and the KYN/TRPratio were significantly lower after seven days (p-values < 0.001). In the deceased group, no significant differences were found between the measurements. Conclusion: Kynurenine and the KYN/TRP ratio are potentially useful parameters in predicting the survival outcome in SARS-CoV-2 positive patients.
KynurenineSARS-CoV-2Tryptophan
Michaelis S.、Zelzer S.、Schnedl W.J.、Baranyi A.、Meinitzer A.、Enko D.
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Institute of Clinical Chemistry and Laboratory Medicine General Hospital Hochsteiermark
Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Graz
Practice for General Internal Medicine
Department of Psychiatry and Psychotherapeutic Medicine Medical University of Graz
NSTL
Elsevier
