Fitoterapia2022，Vol.15910.DOI:10.1016/j.fitote.2022.105137

Four new polycyclic polyprenylated acylphloroglucinols from Hypericum wilsonii and their glucose uptake bioactivities

Cheng, Haitao Zhang, Lulu Wang, Sisi Deng, Jingtong Zhou, Xiuteng Liu, Yang Yang, Xinzhou
Fitoterapia2022，Vol.15910.DOI:10.1016/j.fitote.2022.105137
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  • NSTL
  • Elsevier

Four new polycyclic polyprenylated acylphloroglucinols from Hypericum wilsonii and their glucose uptake bioactivities

Cheng, Haitao 1Zhang, Lulu 1Wang, Sisi 1Deng, Jingtong 1Zhou, Xiuteng 2Liu, Yang 3Yang, Xinzhou1
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作者信息

  • 1. South Cent Minzu Univ
  • 2. China Acad Chinese Med Sci
  • 3. Wuchang Univ Technol
  • 折叠

Abstract

Wilsonglucinols H-K (1-4), four new polycyclic polyprenylated acylphloroglucinols (PPAPs), and eight known compounds (5-12) were isolated and identified from the aerial parts of Hypericum wilsonii. Their planner structures were confirmed via extensive NMR and HRESIMS data analysis. The absolute configurations of the new compounds were mainly determined by NMR calculation and electronic circular dichroism (ECD) calcula-tion. Compounds 1, 6, 8, and 10 showed glucose uptake activities at 30 mu g/mL, in which compound 6 showed the strongest effect and increased the glucose uptake by 2.73 folds.

Key words

Hypericum wilsonii/PPAPs/NMR calculation/ECD calculation/Glucose uptake/Wilsonglucinols H -K/PHLOROGLUCINOL DERIVATIVES/PRENYLATED PHLOROGLUCINOL/PLASMA-MEMBRANE/A-C/PREDICTION/FUSION

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出版年

2022
Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
被引量1
参考文献量35
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