Synthesis of amines via coupling of imines and alkylarenes
Nair, Vaishnavi N. 1Tambar, Uttam K.1
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作者信息
1. Univ Texas Southwestern Med Ctr
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Abstract
Recent advances in selective C-H functionalization have resulted in powerful strategies for the synthesis of important target molecules from petroleum-derived hydrocarbons. In particular, alkylarenes such as toluene and xylenes are abundant feedstock chemicals that are emerging as useful substrates in C-C and C-X bond forming reactions. We review benzylic C-H functionalization of alkylarenes for the synthesis of amines. We focus on the direct coupling of alkylarenes and imines through two distinct modes of activation: heterolytic and homolytic cleavage of benzylic C-H bonds.(c) 2022 Elsevier Ltd. All rights reserved.
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Elsevier