Phytochemistry2022，Vol.19611.DOI:10.1016/j.phytochem.2021.113072

Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads

Petersen, Malene J. Liang, Chao Kjaerulff, Louise Ndi, Chi Semple, Susan Buirchell, Bevan Coriani, Sonia Moller, Birger Lindberg Staerk, Dan
Phytochemistry2022，Vol.19611.DOI:10.1016/j.phytochem.2021.113072
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  • NSTL
  • Elsevier

Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads

Petersen, Malene J. 1Liang, Chao 1Kjaerulff, Louise 1Ndi, Chi 2Semple, Susan 2Buirchell, Bevan 3Coriani, Sonia 4Moller, Birger Lindberg 1Staerk, Dan1
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作者信息

  • 1. Univ Copenhagen
  • 2. Univ South Australia
  • 3. Wise Owl Consulting
  • 4. Tech Univ Denmark
  • 折叠

Abstract

Eremophila (Scrophulariaceae) is a genus of Australian desert plants, which have been used by Australian Aboriginal people for various medicinal purposes. Crude extracts of the leaf resin of Eremophila glabra (R.Br.) Ostenf. showed alpha-glucosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC50 values of 19.3 +/- 1.2 mu g/mL and 11.8 +/- 2.1 mu g/mL, respectively. Dual alpha-glucosidase/PTP1B high-resolution inhibition profiling combined with HPLC-PDA-HRMS and NMR were used to isolate and identify the compounds providing these activities. This resulted in isolation of seven undescribed serrulatane diterpenoids, eremoglabrane A-G, together with nine previously identified serrulatane diterpenoids and flavonoids. Three of the serrulatane diterpenoids showed PTP1B inhibitory activities with IC50 values from 63.8 +/- 5.8 mu M to 104.5 +/- 25.9 mu M.

Key words

Eremophila glabra/Scrophulariaceae/High-resolution inhibition profiling/Serrulatane diterpenoids/Flavonoids Protein-tyrosine phosphatase 1B/alpha-Glucosidase/PTP1B/IDENTIFICATION/CONSTITUENTS/CHEMISTRY

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出版年

2022
Phytochemistry

Phytochemistry

CCR
ISSN：0031-9422
被引量9
参考文献量36
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