首页|Pharmacokinetics of CamSA, a potential prophylactic compound against Clostridioides difficile infections
Pharmacokinetics of CamSA, a potential prophylactic compound against Clostridioides difficile infections
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NSTL
Elsevier
Clostridioides difficile infections (CDI) are the leading cause of nosocomial antibiotic-associated diarrhea. C. difficile produces dormant spores that serve as infectious agents. Bile salts in the gastrointestinal tract signal spores to germinate into toxin-producing cells. As spore germination is required for CDI onset, anti-germination compounds may serve as prophylactics. CamSA, a synthetic bile salt, was previously shown to inhibit C. difficile spore germination in vitro and in vivo. Unexpectedly, a single dose of CamSA was sufficient to offer multi-day protection from CDI in mice without any observable toxicity.
NSTL
Elsevier
