首页|Synthesis and characterization of curcumin-loaded pH/reduction dual-responsive folic acid modified carboxymethyl cellulose-based microcapsules for targeted drug delivery
Synthesis and characterization of curcumin-loaded pH/reduction dual-responsive folic acid modified carboxymethyl cellulose-based microcapsules for targeted drug delivery
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NSTL
Elsevier
ABSTR A C T In the present study, an eco-friendly, biodegradable, biocompatible, non-immunogenic, non-toxic polysaccharide, carboxymethyl cellulose (CMC), derivatived from renewable biomass cellulose, was used for designing and fabrication a folic acid modified pH and reduction dual-responsive carboxymethyl cellulose-based microcapsules (FA-PRCMCs). The curcumin (CUR)-loaded microcapsules (FA-PRCMCs@CUR) were prepared via a quick, efficient and environment-friendly sonochemical method, and were employed for the targeted delivery and pH/reduction dual-stimuli-responsive release of CUR. The excess CUR and ethyl acetate phases could be recycled and reused after preparation of FA-PRCMCs@CUR to avoid wasting resources and polluting the environment. The obtained FA-PRCMCs showed good biocompatibility and targeting in anti-tumor evaluation and endocytosis evaluation in vitro. FA-PRCMCs could effectively reduce the unnecessary damage to normal cells by chemotherapy drugs, and improve the utilization of chemotherapy drugs to reduce therapy costs. FA-PRCMCs could be used as smart targeted delivery vectors and have great clinical application potential. (c) 2021 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
Folic acidReductive-responsiveCarboxymethyl celluloseMicrocapsuleCurcuminTargeted deliverySonochemicalMAGNETIC PROTEIN MICROCAPSULESGRAPHENE OXIDENANOPARTICLESFABRICATIONADRIAMYCINDESIGN
NSTL
Elsevier
