Seven previously undescribed cadinane sesquiterpenoids, albocinnamins A.G, were isolated from the fungus Antrodiella albocinnamomea. Their structures with absolute configurations were elucidated on the basis of extensive spectroscopic methods, as well as single crystal X-ray diffraction. Cadinane sesquiterpenoids were reported from A. albocinnamomea for the first time. All of these sesquiterpenoids possess an unusual ether ring with minor modifications. Albocinnamins D and G showed certain inhibitory activities against nitric oxide production in LPS-activated RAW264.7 macrophages with IC50 values of 26.1 and 19.2 mu M, respectively.
Key words
Antrodiella albocinnamomea/Polyporaceae/Cadinane sesquiterpenoids/Albocinnamins A-G/Structural elucidation/NO production Inhibition/CULTURES
NSTL
Elsevier