首页|Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures

Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures

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  • NSTL
  • Elsevier
A comprehensive and standardized system to report lipid structures analyzed by MS is essential for the communication and storage of lipidomics data. Herein, an update on both the LIPID MAPS classification system and shorthand notation of lipid structures is presented for lipid categories Fatty Acyls (FA), Glycerolipids (GL), Glycerophospholipids (GP), Sphingolipids (SP), and Sterols (ST). With its major changes, i.e., annotation of ring double bond equivalents and number of oxygens, the updated shorthand notation facilitates reporting of newly delineated oxygenated lipid species as well. For standardized reporting in lipidomics, the hierarchical architecture of shorthand notation reflects the diverse structural resolution powers provided by mass spectrometric assays. Moreover, shorthand notation is expanded beyond mammalian phyla to lipids from plant and yeast phyla. Finally, annotation of atoms is included for the use of stable isotope-labeled compounds in metabolic labeling experiments or as internal standards. This update on lipid classification, nomenclature, and shorthand annotation for lipid mass spectra is considered a standard for lipid data presentation.

mass spectrometrylipidomicsfatty acylsglycerolipidsglycerophospholipidssphingolipidssterols

Durand, Thierry、Ejsing, Christer S.、Fedorova, Maria、Feussner, Ivo、Griffiths, William J.、Koefeler, Harald、Merrill, Alfred H., Jr.、Murphy, Robert C.、O'Donnell, Valerie B.、Oskolkova, Olga、Subramaniam, Shankar、Wakelam, Michael J. O.、Spener, Friedrich、Liebisch, Gerhard、Fahy, Eoin、Aoki, Junken、Dennis, Edward A.

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Univ Montpellier, CNRS, Inst Biomol Max Mousseron, ENSCM, Montpellier, France

Univ Southern Denmark, Dept Biochem & Mol Biol, Villum Ctr Bioanalyt Sci, Odense, Denmark

Univ Leipzig, Inst Bioanalyt Chem, Fac Chem & Mineral, Leipzig, Germany

Univ Gottingen, Dept Plant Biochem, Albrecht von Haller Inst, Gottingen, Germany

Swansea Univ, Med Sch, Swansea, W Glam, Wales

Med Univ Graz, Core Facil Mass Spectrometry, Graz, Austria

Georgia Inst Technol, Sch Biol Sci, Atlanta, GA 30332 USA

Univ Colorado Denver, Dept Pharmacol, Aurora, CO USA

Cardiff Univ, Syst Immun Inst, Cardiff, Wales

Karl Franzens Univ Graz, Inst Pharmaceut Sci, Graz, Austria

Univ Calif San Diego, Dept Biomed Engn, Jacobs Sch Engn, La Jolla, CA 92093 USA

Babraham Inst, Babraham Res Campus, Cambridge, England

Karl Franzens Univ Graz, Dept Mol Biosci, Graz, Austria

Regensburg Univ Hosp, Inst Clin Chem & Lab Med, Regensburg, Germany

Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo, Japan

Univ Calif San Diego, Sch Med, Dept Pharmacol, Dept Chem & Biochem, La Jolla, CA 92093 USA

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2020

10.1194/jlr.S120001025

Journal of lipid research.

Journal of lipid research.

ISSN：0022-2275
年,卷(期)：2020.61(12)
  • 137
  • 36