Fitoterapia2022，Vol.1567.DOI:10.1016/j.fitote.2021.105085

New iboga-type alkaloids from Ervatamia officinalis and their anti-inflammatory activity

Tang B.-Q. Yu G.-D. Li Z.-W. Chang Y. Zhang X.-Q. Li L. Bian Y.-Q. Lee S.M.-Y. Li B.-J.
Fitoterapia2022，Vol.1567.DOI:10.1016/j.fitote.2021.105085
✕
  • NSTL
  • Elsevier

New iboga-type alkaloids from Ervatamia officinalis and their anti-inflammatory activity

Tang B.-Q. 1Yu G.-D. 1Li Z.-W. 2Chang Y. 2Zhang X.-Q. 2Li L. 3Bian Y.-Q. 3Lee S.M.-Y. 3Li B.-J.4
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作者信息

  • 1. Department of Medical Science Shunde Polytechnic
  • 2. NMPA Key Laboratory for Quality Evaluation of TCM Jinan University
  • 3. State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau
  • 4. College of Traditional Chinese Medicine Yunnan University of Chinese Medicine
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Abstract

© 2021 Elsevier B.V.Four new iboga-type alkaloids, ervaoffines H-K (1–4), along with five known compounds were obtained from the aerial parts of Ervatamia officinalis. The absolute configurations of 1–4 were confirmed by X-ray diffraction and electronic circular dichroism (ECD) analyses. The isolates were tested for their anti-inflammatory activity. Compounds 1, 5, 6, and 9 showed potential inhibitory effect of NO production in LPS-stimulated BV2 and RAW264.7 cells.

Key words

Anti-inflammatory/Ervaoffines/Ervatamia officinalis/Iboga-type alkaloids/NO release

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出版年

2022
Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
被引量3
参考文献量17
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