首页|Cyclometalated iridium(III)complexes containing bithiazole ligands for preferable viscosity detection
Cyclometalated iridium(III)complexes containing bithiazole ligands for preferable viscosity detection
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NSTL
Detecting viscosity is vital for pathological investigation since subtle changes in cellular microviscosity are related to pathologies and diseases.In this work,five cationic Ir(III)complexes Irl-Ir5 with the formulas as[Ir(ppy)2L]PF6 have been synthesized,where L1-L5 are a family of coplanar bithiazole derivatives having versatile donor/acceptor tails(proton,bromo,tetraphenylethylene,benzothiophene,ethyl benzoate).Fluorescent experiment shows that L1-L5 have a fluorescent activity with high quantum yields(Φ>33%).However,the quantum yields of Ir1-Ir5 are weak in the range from 2.7% to 7.7%.There is a linear relationship between Log(I_(620)nm)and Log(viscosity),which can quantitatively measure viscosity in the range of 1.36-669 cP.Furthermore,a cell colocalization experiment has been performed using commercial nuclear dye(DAPI),lysosomal dye(LysoGreen),and mitochondrial dye(MitoGreen)to explore the subcellular localization ability of Irl in living cells,indicating that the probe Irl can easily pass through the cell membrane,and can accurately target lyso-somes in living cells.In addition,complex Irl can quantitatively detect viscosity and target lysosomes,possessing the potential for practical application in intracellular viscosity detection.
Institute of Advanced Materials and Flexible Electronics(IAMFE),School of Chemistry and Materials Science,Nanjing University of Information Science & Technology(NUIST),Nanjing,210044,PR China
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