首页|Three new D:A Friedo-oleanane triterpenes from the stem bark of Anacolosa poilanei and their cytotoxic activities

Three new D:A Friedo-oleanane triterpenes from the stem bark of Anacolosa poilanei and their cytotoxic activities

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? 2021Three new D:A friedo-oleanane triterpenes, 3α-p-coumaroyl-D:A-friedo-oleanan-27-oic acid (1), 3α-(3,4-dihydroxycinnamoyl)-D:A-friedo-oleanan-27-oic acid (2), and 3α-(3,4-dihydroxycinnamoyl)-D:A-friedo-oleanan-27,15α-lactone (3) along with three known compounds, trichadenic acid A (4), trichadonic acid (5), and amentoflavone (6), were isolated from the stem barks of Anacolosa poilanei Gagnep. Their structures were established by spectral analysis, such as mass spectrometry, 1D-NMR, and 2D-NMR. Compound 1 exhibited cytotoxicity against LU-1, HepG2, MCF7, and KB cell lines. Compounds 2 and 3 were more active against KB and HepG2 compared to the LU-1 and MCF7 cells.

Anacolosa poilaneicytotoxicityD:A friedo-oleanane triterpenesOlacaceaetrichadenic acid

Le H.T.、Doan T.T.A.、Nguyen T.L.、Phi T.D.、Doan T.M.H.、Pham V.C.、Litaudon M.

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School of Chemical Engineering Hanoi University of Science and Technology

Institute of Marine Biochemistry (IMBC) Vietnam Academy of Science and Technology (VAST)

Institut de Chimie des Substances Naturelles CNRS-ICSN UPR 2301 Université Paris-Saclay

2022

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN:1874-3900
年,卷(期):2022.47
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