首页|Anti-inflammatory sesquiterpenoid dimers from Artemisia atrovirens

Anti-inflammatory sesquiterpenoid dimers from Artemisia atrovirens

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  • NSTL
  • Elsevier
Eight new sesquiterpenoid dimers, artatrovirenolides A-H (1-8), along with three known analogues (9-11), were isolated from Artemisia atrovirens by using the LC-MS guided isolation. Compound 1 was a compound dimerized from a guaianolide and a 1,10-seco-guaianolide unit while others were from two guaianolide units. Their structures were established by comprehensive analysis of spectroscopic data, and their absolute configurations were determined by the aid of time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculation. Compound 8 showed anti-inflammatory effect in LPS-stimulated BV-2 microglial cells at 1 mu M, while compounds 1, 2, 5, and 6 inhibited microglial inflammation at 10 mu M.

Artemisia atrovirensSesquiterpenoid dimerGuaianolideTDDFT ECD calculationArtatrovirenolides A-HGUAIANOLIDESLACTONES

Shao, Zhengguang、Li, Lizhi、Zheng, Yongzhe、Gong, Qi、Ke, Chang-Qiang、Yao, Sheng、Zhang, Haiyan、Tang, Chunping、Ye, Yang

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Chinese Acad Sci

Univ Chinese Acad Sci

2022

10.1016/j.fitote.2022.105199

Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
年,卷(期)：2022.159
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