首页|Sugar easters and xanthones from the roots of Polygala tenuifolia Willd. and their cytoprotective activity

Sugar easters and xanthones from the roots of Polygala tenuifolia Willd. and their cytoprotective activity

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  • NSTL
  • Elsevier
? 2022 Elsevier B.V.Six new sugar esters (1–6), named tenuifolisides F-G (1–2) and tenuifolioses W-Z (3–6), together with 16 known compounds (7–22) were isolated from the roots of Polygala tenuifolia. The chemical structures of the new compounds were elucidated by 1D, 2D NMR and HRESIMS techniques together with chemical methods. All the compounds were evaluated for the cytoprotective activity against hydrogen peroxide (H2O2)-induced oxidative stress in human keratinocyte HaCaT cells. Compounds 4, 5, 13, 20 and 22 showed strong cytoprotective effect.

Cytoprotective activityHaCaT cellsPolygala tenuifoliaSugar esters

Wang M.-K.、Li X.-J.、Yu K.、Yang B.-B.、Jiang X.-L.、Wang L.、Li F.

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Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of Biology Chinese Academy of Sciences

School of Life Sciences Southwest Jiaotong University

2022

10.1016/j.fitote.2022.105256

Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
年,卷(期)：2022.161
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