首页|SECONDARY METABOLITES FROM THE MANGROVE-DERIVED FUNGUS Penicillium verruculosum AND THEIR BIOACTIVITIES
SECONDARY METABOLITES FROM THE MANGROVE-DERIVED FUNGUS Penicillium verruculosum AND THEIR BIOACTIVITIES
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
Marine-derived fungi have been proved to be an important source of diverse secondary metabolites with novel structures and potent bioactivities, which are considered as one of the potential sources of drug lead compounds [1,2]. Among them, Penicillium is one of the largest and most intensively investigated fungal genus. To date, a large number of bioactive compounds, such as alkaloids, polyketides, terpenoids, steroids, and cyclic peptides, have been isolated from marine-derived fungi of Penicillium species [1-3]. In our ongoing search for new bioactive secondary metabolites from mangrove-derived fungus [4-6], the fungus Penicillium verruculosum TGM14 attracted our attention because its EtOAc extract showed a-glucosidase inhibitory activity. Investigation of this EtOAc extract led to the isolation of 13 compounds, including five sterols (1-5), two phenolic C-glycosides (6, 7), three phenolic derivatives (8-10), and three nitrogenous compounds (11-13). Herein, we report the isolation, structure elucidation, and biological activities of these compounds.
Bin Wang、Qian-Hui Chen、Ting Jiang
展开 >
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, Hainan, P. R. China
NSTL
