首页|A NEW CHLORINATED TETRALONE FROM CO-CULTURE OF INSECT-PATHOGENIC Beauveria bassiana AND PHYTOPATHOGENIC Nigrospora oryzae
A NEW CHLORINATED TETRALONE FROM CO-CULTURE OF INSECT-PATHOGENIC Beauveria bassiana AND PHYTOPATHOGENIC Nigrospora oryzae
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In this study,the co-culture of Nigrospora oryzae and Beauveria bassiana,the pathogenic endophytes in the seeds of Dendrobium officinale,were examined for their antagonistic relationship by the production of metabolite.One new chlorotetralone(1)and five known compounds,murranoic acid A(2),9,12,13-trihydroxy-10-octadecenoic acid(3),3,3'-methylenebis(4-hydroxy-6-methyl-2H-pyran-2-one)(4),sclerin(5),and(4S)-4,6,8-trihydroxy-3,4-dihydro-1(2H)-naphthalen-1-one(6),were isolated.Compounds 1-5 showed antifungal activity against B.bassiana with MICs of 256,128,2,32,and 64 μg/mL,and N.oryzae with MICs of 64,256,256,256,and 64 μg/mL.Compound 4 showed significant antifungal activity against co-culture of B.bassiana and N.oryzae with MIC at 1 μg/mL.
Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province,Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry Education and Yunnan Province,School of Chemical Science and Technology,Yunnan Univer
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