Transition-Metal-Free Synthesis of Symmetrical 1,4-Diarylsubstituted 1,3-Diynes by Iodine-Mediated Decarboxylative Homocoupling of Arylpropiolic Acids
Ghosh, Subhankar 1Chattopadhyay, Shital Kumar1
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作者信息
1. Univ Kalyani
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Abstract
An efficient metal-free method for the synthesis of symmetrical 1,3-diynes through iodine-mediated decarboxylative homocoupling of aryl propiolic acids was developed. This iodine-mediated decarboxyla-tive homocoupling reaction by Csp-Csp bond formation in DMSO underwent smoothly to afford the cor-responding 1,4-disubstituted 1,3-dialkynes in good to excellent yields. This operationally simple and environmentally benign protocol avoids the use of sophisticated ligands, additional oxidants and expen-sive transition metal/reagents.(c) 2022 Elsevier Ltd. All rights reserved.
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Elsevier