Visible-light induced green synthesis of y-deuterated carbonyl compounds
Hu, Lifu 1Li, Ruining 1Deng, Wei 1Sun, Zhankui1
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作者信息
1. Shanghai Jiao Tong Univ
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Abstract
Deuteration isa widely used labelling technique. Through a visible-light induced desulfurization and rad-ical addition process in EtOAc-D2O, we were able to develop the direct synthesis of y-deuterated carbonyl compounds from a-sulfide ketones and alkenes. Products with different functionalities were efficiently synthesized with high-deuteration. This mild and metal-free method provides a valuable tool for medic-inal and synthetic chemists. (C) 2022 Elsevier Ltd. All rights reserved.
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Elsevier