24-EPIMARKHACANASIN С, AN EPIMERIC CYCLOARTANE-TYPE TRITERPENOID FROM THE LEAVES OF Markhamia stipulata var. canaense

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外文摘要：One new cycloartane-type triterpenoid, named 24-epimarkhacanasin С (1), together with four known flavonoids, apigenin (2), luteolin (3), apigenin 7-0-(3-D-glucopyranoside (4), and luteolin 7-0-f3-D-glucopyranoside (5), was isolated by various chromatographic methods from the ethyl acetate extract of Markhamia stipulata var. canaense leaves. Their structures were elucidated by IR, UV, HR-ESI-MS, and NMR experiments. All compounds were reported for the first time from this species. Their cytotoxicities were evaluated against human breast cancer cell line (MCF-7) by SRB assay. The isolated compounds 1, 3, and 4 exhibited significant cytotoxic activity (IC50 ranged from 53.38 to 68.32 ug/mL), while compounds 2 and .5 did not show activity.

外文关键词：

Markhamia stipulata var. canaenseBignoniaceae24-epimarkhacanasin Ccytotoxic activity.

作者：

Trong Nghia Ngo、Ngoc Thien Ly Nguyen、Nhat Minh Phan

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作者单位：

Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, 100000, Hanoi, Vietnam

Tan Hiep High School, 920000, Kien Giang Province, Vietnam

Institute of Chemical Technology, Vietnam Academy of Science and Technology, 700000, Ho Chi Minh City, Vietnam

出版年：

2021

Химия природных соединений

ISSN：0023-1150

年,卷(期)：2021.(5)