首页|The impact of the intestinal microbiota and the mucosal permeability on three different antibiotic drugs

The impact of the intestinal microbiota and the mucosal permeability on three different antibiotic drugs

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  • NSTL
  • Elsevier
BackgroundThe totality of bacteria, protozoa, viruses and fungi that lives in the human body is called microbiota. Human microbiota specifically colonizes the skin, the respiratory and urinary tract, the urogenital tract and the gastrointestinal system. This study focuses on the intestinal microbiota to explore the drug-microbiota relationship and, therefore, how the drug bioavailability changes in relation to the microbiota biodiversity to identify more personalized therapies, with the minimum risk of side effects. MethodsTo achieve this goal, we developed a new mathematical model with two compartments, the intestine and the blood, which takes into account the colonic mucosal permeability variation - measured by Ussing chamber system on human colonic mucosal biopsies - and the fecal microbiota composition, determined through microbiota 16S rRNA sequencing analysis. Both of the clinical parameters were evaluated in a group of Irritable Bowel Syndrome patients compared to a group of healthy controls. Key ResultsThe results show that plasma drug concentration increases as bacterial concentration decreases, while it decreases as intestinal length decreases too. ConclusionsThe study provides interesting data since in literature there are not yet mathematical models with these features, in which the importance of intestinal microbiota, the "forgotten organ", is considered both for the subject health state and in the nutrients and drugs metabolism.

Intestinal microbiotaDrug bioavailabilityCompartmental modelsGut barrier function

Palombo, Giovanni、Merone, Mario、Altomare, Annamaria、Gori, Manuele、Terradura, Carlotta、Bacco, Luca、Del Chierico, Federica、Putignani, Lorenza、Cicala, Michele、Guarino, Michele Pier Luca、Piemonte, Vincenzo

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IASI CNR Natl Res Council Italy, Ist Anal Sistemi Informat A Ruberti, Rome, Italy

Univ Campus Biomed, Dept Engn, Comp Syst & Bioinformat Lab, Rome, Italy

Campus Biomed Univ, Unit Gastroenterol, Rome, Italy

Univ Campus Biomed Rome, Dept Engn, Unit Chem Phys Fundamentals Chem Engn, Rome, Italy

IRCCS, Bambino Gesu Childrens Hosp, Unit Human Microbiome, Multimodal Lab Med Res Area, Rome, Italy

IRCCS, Bambino Gesu Childrens Hosp, Unit Human Microbiome, Dept Diagnost & Lab Med,Unit Parasitol &

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2021

10.1016/j.ejps.2021.105869

European journal of pharmaceutical sciences

European journal of pharmaceutical sciences

ISTP
ISSN：0928-0987
年,卷(期)：2021.164
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