首页|Chlorinated bisabolene sesquiterpenoids from the whole plant of Parasenecio rubescens

Chlorinated bisabolene sesquiterpenoids from the whole plant of Parasenecio rubescens

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  • NSTL
  • Elsevier
? 2021 Elsevier B.V.Four new chlorinated bisabolene-type sesquiterpenoids (1–4) were isolated during the phytochemical investigation of an acetone extract of the whole plant of Parasenecio rubescens. The structures of 1–4 were determined by analysis of their HRESIMS and NMR spectroscopic data, and the absolute configuration of 1 was established through single-crystal X-ray diffraction. All isolates were evaluated for their cytotoxicity against three cancer cell lines (B16 mouse melanoma, HepG2 human hepatocellular carcinoma, and MCF7 human breast adenocarcinoma), as well as their antimicrobial effects against Staphylococcus aureus, Escherichia coli, and Monilia albicans. As a result, compounds 1–4 displayed a certain degree of antimicrobial activities.

Absolute configurationAntimicrobial activitiesChlorinated bisabolene sesquiterpenoidsCompositaeParasenecio rubescens

Jin A.、Duan F.、Chang J.、Ruan H.、Liu S.

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School of Pharmacy Tongji Medical College of Huazhong University of Science and Technology Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation

School of Pharmaceutical Sciences Hunan University of Medicine

2022

10.1016/j.fitote.2021.105093

Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
年,卷(期)：2022.156
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