首页|Biocompatible and Photostable Photoacoustic Contrast Agents as Nanoparticles Based on Bodipy Scaffold and Polylactide Polymers:Synthesis,Formulation,and In Vivo Evaluation

Biocompatible and Photostable Photoacoustic Contrast Agents as Nanoparticles Based on Bodipy Scaffold and Polylactide Polymers:Synthesis,Formulation,and In Vivo Evaluation

扫码查看
原文链接
  • NSTL
We have designed a new Bodipy scaffold for efficient in vivo photoacoustic(PA) imaging of nanoparticles commonly used as drug nanovectors.The new dye has an optimized absorption band in the near-infrared window in biological tissue and a low fluorescence quantum yield that leads to a good photoacoustic generation efficiency.After Bodipy-initiated ring-opening polymerization of lactide,the polylactide-Bodipy was formulated into PEGylated nanoparticles(NPs) by mixing with PLA-PEG at different concentrations.Formulated NPs around 100 nm exhibit excellent PA properties:an absorption band at 760 nm and a molar absorption coefficient in between that of molecular PA absorbers and gold NPs.Highly improved photostability compared to cyanine-labeled PLA NPs as well as innocuity in cultured macrophages were demonstrated,After intravenous injection in healthy animals,NPs were easily detected using a commercial PA imaging system and spectral unmixing,opening the way to their use as theranostic agents.

photoacoustic imagingnanoparticlesBodipycontrast agentspolylactide

Jean-Baptiste Bodin、Jerome Gateau、Justine Cois

展开 >

Universite Paris-Saclay,CNRS,Institut des Sciences Moleculaires d'Orsay,9140S Orsay,France

Sorbonne Universite,CNRS,INSERM,Laboratoire d'Imagerie Biomedicale,LIB,F-7S006 Paris,France

Universite Paris-Saclay,ENS Paris-Saclay,CNRS,PPSM,91190 Gif-sur-Yvette,France

2022

10.1021/acsami.2c04874

ACS applied materials & interfaces

ACS applied materials & interfaces

SCI
ISSN：1944-8244
年,卷(期)：2022.14(36)
  • 1
  • 58