首页|Increased serum C1q/TNF-related protein 4 concentration in patients with acute coronary syndrome
Increased serum C1q/TNF-related protein 4 concentration in patients with acute coronary syndrome
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NSTL
Elsevier
? 2021 Elsevier B.V.Accumulated evidence have revealed profound associations between C1q/TNF-related proteins (CTRPs) and coronary artery disease (CAD); yet, the relationship of CTRP4 to CAD has not been investigated. We examined the role of CTRP4 in CAD, and especially in acute coronary syndrome (ACS). Methods: A total of 138 patients referred for coronary angiography were included in this study and were classified into 3 groups (ACS, CAD and control group). Comparisons regarding clinical data and CTRP4 concentration were performed among 3 groups. Weighted least-squares regression analysis was used to identify the independent predicting factors for CTRP4. Results: Compared with either CAD (median 7.19 vs. 9.43, P < 0.05) or control group (median 7.22 vs. 9.43, P < 0.01), ACS group showed higher CTRP4 concentration. In addition, trend χ2 test revealed the presence of ACS increased with increased CTRP4 concentration (P = 0.010). Finally, in the weighted least-squares regression analysis, ACS was the only independent variable influencing CTRP4 concentration (β- coefficient = 3.082, P = 0.004), even after adjusting for high-sensitivity C reactive protein (β- coefficient = 3.050, P = 0.007). Conclusions: CTRP4 was associated with ACS; moreover, ACS was the independent factor in predicting CTRP4 concentration. The potentially important implications of CTRP4 in ACS may offer a novel insight into understanding the link between inflammation and ACS.
Acute coronary syndromeC1q/TNF-related protein 4Coronary artery diseaseInflammation
Dai Y.、Zhou J.、Niu L.、Hu J.、Han J.
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Department of Cardiology the First Affiliated Hospital of Soochow University
Department of Endocrinology the First Affiliated Hospital of Soochow University
NSTL
Elsevier
