首页|Association of in-hospital depression and anxiety symptoms following stroke with 3 months- depression, anxiety and functional outcome
Association of in-hospital depression and anxiety symptoms following stroke with 3 months- depression, anxiety and functional outcome
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NSTL
Elsevier
? 2022 Elsevier LtdBackground: Post-stroke depression and anxiety are common and are associated with worse post-stroke outcomes. Even though checking for depression during stroke hospitalization has become a common practice, the prognostic value of a positive in-hospital depression screen following stroke remains unclear. Methods: This is a retrospective cohort study of patients with stroke or TIA discharged home from a tertiary care center. We examined the association between premorbid history of depression and in-hospital anxiety/depressive symptoms, with anxiety/depressive symptoms and functional outcome at 3-months post-stroke. Logistic regression models were generated using two different main predictors: 1) pre-hospital history of depression (N = 117) and 2) in-hospital depression/anxiety measured by the EQ-5D-3L (N = 66). Results: In the cohort of 117 patients, the mean age was 66 years, with median NIHSS 2;44% were women and 70% White. A history of pre-stroke depression was reported by 7% (8/117). Anxiety/depression on ED-5D-3L was reported by 29/66 (43%) in the hospital and by 22/66 (33%) at three months’ post-stroke. In the first adjusted model, previous history of depression was associated with 3 months EQ-5D-3L anxiety/depression (OR = 10.2;95%CI:1.12–90.9, p = 0.038). In the second adjusted model, in-hospital anxiety/depression was associated with 3-month EQ-5D-3L anxiety/depression (OR = 3.9; 95% CI:1.16–13.1, p = 0.027). In-hospital anxiety/depression was associated with a higher mRS at 3 months but not after adjusting for covariates. Conclusion: A previous history of depression and in-hospital anxiety/depression symptoms are associated with anxiety/depression symptoms 3-months post-stroke but not with functional outcome. Screening stroke patients for both during hospitalization is warranted because of the association with later symptoms.
AnxietyDepression after strokeED-Q5-3LStroke
Ambrosius W.T.、Bishop L.、Gesell S.、Prvu-Bettger J.、El Husseini N.、Redmond C.、Bushnell C.、Duncan P.、D'Agostino Jr R.
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Department of Biostatistical Sciences Public Health Sciences Wake Forest School of Medicine
Department of Neurology Medical University of South Carolina
Department of Social Sciences and Health Policy Public Health Sciences Wake Forest School of
Department of Orthopedic Surgery Duke University School of Medicine
Department of Neurology Wake Forest Baptist Medical Center
NSTL
Elsevier
