首页|Risk factors for development of long-term mood and anxiety disorder after pediatric traumatic brain injury: a population-based, birth cohort analysis

Risk factors for development of long-term mood and anxiety disorder after pediatric traumatic brain injury: a population-based, birth cohort analysis

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  • Taylor & Francis
Objectives The objective of this study was to identify characteristics associated with an increased risk of anxiety and mood disorder prior to 25 years of age， in children who sustained a traumatic brain injury (TBI) prior to age 10。 Methods This population-based study identified 562 TBI cases from a 1976-1982 birth cohort in Olmsted County， Minnesota。 TBI cases were manually confirmed and classified by injury severity。 Separate Cox proportional hazards regression models were fit to estimate the association of TBI and secondary non-TBI related characteristics with the risk of a subsequent clinically determined anxiety or mood disorder。 Multivariable-adjusted population attributable risk (PAR) estimates were calculated for TBI characteristics。 Results Older age at initial TBI and extracranial injury at time of initial TBI were significantly associated with an increased risk of anxiety (adjusted HR [95% CI]: 1。33 [1。16， 1。52] per 1-year increase and 2。41 [1。26， 4。59])， respectively。 Older age at initial TBI was significantly associated with an increased risk of a mood disorder (adjusted HR 1。17 [1。08-1。27])。 Conclusion In individuals sustaining a TBI prior to age 10， age at injury greater than 5 years old was the largest contributor to development of a mood or anxiety disorder。

Brain injuriestraumaticpsychiatry and psychologybrain diseasesdepressive disordersanxiety disordersbipolar disorderMEDICAL-RECORDS-LINKAGEADOLESCENTS 24 MONTHS1ST 6 MONTHSPSYCHIATRIC-DISORDERSSOCIOECONOMIC-STATUSUNITED-STATESROCHESTERCHILDRENEPIDEMIOLOGYCHILDHOOD

Esterov, Dmitry、Witkowski, Julie、McCall, Dana M.、Wi, Chung-Il、Weaver, Amy L.、Brown, Allen W.

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Coll Med & Sci,Mayo Clin

Sch Grad Med Educ,Mayo Clin

2022

10.1080/02699052.2022.2077987

Brain injury

Brain injury

SCI
ISSN：0269-9052
年,卷(期)：2022.36(6)
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