Cytotoxic new caged-polyprenylated xanthonoids from Garcinia oligantha
Liu, Qingying 1Zheng, Hao 1Wang, Xiaoning 1Zhou, Lu 1Wang, Shuqi 1Shen, Tao 1Ren, Dongmei1
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作者信息
1. Shandong Univ
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Abstract
Caged-polyprenylated xanthonoids represent a rare class of natural products. This type of compounds is mainly isolated from Genus Garcinia. Phytochemical studies on the leaves and twigs of Garcinia oligantha led to the isolation of four new caged-polyprenylated xanthonoids, oliganthone C-F (1-4), and two new simple xanthones (5-6), oliganthaxanthone D and oliganthaxanthone E. Eight known other polyprenylated xanthones (7-14) including five caged-polyprenylated xanthonoids (7-11) were also isolated. Their structures were elucidated based on the analyses of extensive spectroscopic data. All the isolated compounds except for 5, 6 and 14 showed cell viability reducing effect against human lung cancer A549 cells. Compounds 1-3 were proved to be potential apoptosis inducing agents.
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