Asymmetric syntheses of (-)-hedyosumins A-C via enantioselective Diels-Alder reaction of (E)-Hex-3-en-5-yn-2-one and platinum(II)-catalyzed [3+2]-cyclization
Asymmetric syntheses of (-)-hedyosumins A-C via enantioselective Diels-Alder reaction of (E)-Hex-3-en-5-yn-2-one and platinum(II)-catalyzed [3+2]-cyclization
Enantioselective construction of the central [3.2.1] oxa-bicyclic core of hedyosumins A-C was achieved via an enantioselective Diels-Alder reaction and a platinum(II)-catalyzed 1,3-dipolar [3+2] cycloaddition as key steps, which leads to the asymmetric total synthesis of hedyosumins A-C. (c) 2022 Elsevier Ltd. All rights reserved.
Key words
Asymmetric/Total synthesis/hedyosumins A -C/Diels-Alder reaction/3-dipolar [3+2] cycloaddition/CONTAINING CARBONYL YLIDES
NSTL
Elsevier