Abstract
Applications of piperazine and homopiperazine in drug design are well-established,and these heterocycles have found use as both scaffolding and terminal elements and also as a means of introducing a water-solubilizing element into a molecule.In the accompanying review(I0.1021/acs.jafc.2c00726),we summarized applications of piperazine and homopiperazine and their fused ring homologues in bioactive compound design along with illustrations of the use of 4-substituted piperidines and a sulfoximine-based mimetic.In this review,we discuss applications of pyrrolidine-and fused-pyrrolidine-based mimetics of piperazine and homopiperazine and illustrate derivatives of azetidine that include stretched and spirocyclic motifs,along with applications of a series of diarninocycloalkanes.
NSTL