首页|BODIPY-based near-infrared fluorescent probe for diagnosis drug-induced liver injury via imaging of HCIO in cells and in vivo
BODIPY-based near-infrared fluorescent probe for diagnosis drug-induced liver injury via imaging of HCIO in cells and in vivo
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NSTL
Drug-induced liver injury (DILI) as an acute liver disease has caused serious concern in public health problems. As a kind of reactive oxygen species, HCIO has come into scientists' vision as a marker of DILI. Herein, we construct a BODIPY-based near-infrared (NIR) fluorescent probe (BDP-R-CIO) for the selective and sensitive response of hypochlorous acid. The probe could realize the rapid detection of HCIO, with a 20-fold fluorescence enhancement at 661 nm and the detection value of which was only 1.8 nM. Moreover, BDP-R-CIO could diagnose and visualize DILI by monitoring the fluctuation of HCIO concentration in vitro and in vivo, and evaluate the detoxification of hepatoprotective drugs. Through the visualization of HCIO in the mice liver injury models, BDP-R-CIO not only proved its applicability but also indicated that it had great potential in the diagnosis and monitoring of HClO-related diseases.
Key Laboratory for Special Functional Materials of Ministry of Education, School of Materials Science and Engineering, Henan University, Kaifeng, 475004, PR China
NSTL
