首页|Current insight into treatment of chronic rhinosinusitis: Phenotypes, endotypes, and implications for targeted therapeutics

Current insight into treatment of chronic rhinosinusitis: Phenotypes, endotypes, and implications for targeted therapeutics

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  • NSTL
  • Elsevier
Chronic rhinosinusitis is characterized by persistent locoregional mucosal inflammation of the paranasal sinuses and upper airway that has substantial associated health care costs. Personalized approaches to care that incorporate use of molecular biomarkers, phenotypes, and inflammatory endotypes is a major focus of research at this time, and the concurrent rise of targeted therapeutics and biologic therapies has the potential to rapidly advance care and improve outcomes. Recent findings suggest that improved understanding of chronic rhinosinusitis phenotypic and endotypic heterogeneity, and incorporation of these characteristics into clinical care pathways, may facilitate more effective selection of surgical and/or therapeutic interventions. Ultimately, these personalized approaches have the potential to target specific inflammatory pathways, increase efficacy, reduce costs, and limit side effects. This review summarizes recent advances in the identification and characterization of chronic rhinosinusitis phenotypes, endotypes, and biomarkers and reviews potential implications for targeted therapeutics.

EndotypesrhinosinusitisbiomarkersphenotypescytokinesbiologicsEOSINOPHILIC MUCIN RHINOSINUSITISEXACERBATED RESPIRATORY-DISEASECHRONIC HYPERPLASTIC SINUSITISMESSENGER-RNA EXPRESSIONNASAL POLYPSINTERLEUKIN-8 SECRETIONINFLAMMATORY ENDOTYPESCLUSTER-ANALYSISALLERGIC FUNGALORAL STEROIDS

Chapurin, Nikita、Wu, Jeffanie、Labby, Alex B.、Chandra, Rakesh K.、Turner, Justin H.、Chowdhury, Naweed, I

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Dept Otolaryngol Head & Neck Surg,Vanderbilt Univ Sch Med

2022

10.1016/j.jaci.2022.04.013

The Journal of Allergy and Clinical Immunology

The Journal of Allergy and Clinical Immunology

ISSN：0091-6749
年,卷(期)：2022.150(1)
  • 20
  • 97