首页|Compounds from the fruits of Nicandra physaloides and their potential anti-inflammatory activities

Compounds from the fruits of Nicandra physaloides and their potential anti-inflammatory activities

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  • NSTL
  • Elsevier
? 2022 Phytochemical Society of EuropeTwenty-one compounds were isolated and identified from the ethanol extract of the fruits of Nicandra physaloides, including four new (1–4) and 17 known compounds (5–21). All the compounds were isolated from the genus Physalis for the first time. In this study, NMR spectroscopy was used to study the compound structures by comparing their data with those reported in the literature. Moreover, the potential anti-inflammatory activity of RAW264.7 cells induced by lipopolysaccharide (LPS) was evaluated. Among the monoterpenoids, compounds (5–7, 9) exhibited weak anti-inflammatory activities, with IC50 values ranging from 29.10 to 68.30 μM.

Anti-inflammatory activityChemical constituentNicandra physaloidesSolanaceae

Liu Y.、Jiang Y.-K.、Naseem A.、Algradi A.M.、Kuang H.-X.、Yang B.-Y.、Jiang H.-B.、Liu G.-Z.

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Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine) Ministry of Education

Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College

Shandong Qingdao Hospital of Integrated Traditional and Western Medicine

2022

10.1016/j.phytol.2022.01.016

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.48
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