首页|From stem cells to spiral arteries: A journey through early placental development

From stem cells to spiral arteries: A journey through early placental development

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  • NSTL
  • Elsevier
Early placental development lays the foundation of a healthy pregnancy, and numerous tightly regulated processes must occur for the placenta to meet the increasing nutrient and oxygen exchange requirements of the growing fetus later in gestation. Inadequacies in early placental development can result in disorders such as fetal growth restriction that do not present clinically until the second half of gestation. Indeed, growth restricted placentae exhibit impaired placental development and function, including reduced overall placental size, decreased branching of villi and the blood vessels within them, altered trophoblast function, and impaired uterine vascular remodelling, which together combine to reduce placental exchange capacity. This review explores the importance of early placental development across multiple anatomical aspects of placentation, from the stem cells and lineage hierarchies from which villous core cells and trophoblasts arise, through extravillous trophoblast invasion and spiral artery remodelling, and finally remodelling of the larger uterine vessels.

Placental developmentPlacental vasculatureTrophoblast stem cellExtravillous trophoblastSpiral artery remodellingFetal growth restrictionMESENCHYMAL STROMAL CELLSFETAL-GROWTH RESTRICTIONLOW SHEAR-STRESSRNA-SEQ REVEALSEXTRAVILLOUS TROPHOBLAST1ST TRIMESTEREARLY-PREGNANCYINTERVILLOUS SPACEENDOTHELIAL-CELLSBLOOD-FLOW

Sun, Cherry、Allerkamp, Hanna H.、Clark, Alys R.、James, Joanna L.、Boss, Anna L.

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Fac Med & Hlth Sci,Univ Auckland

Auckland Bioengn Inst,Univ Auckland

2022

10.1016/j.placenta.2021.11.004

Placenta

Placenta

ISTP
ISSN：0143-4004
年,卷(期)：2022.125
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