首页|Cross-linked valerolactone copolymer implants with tailorable biodegradation, loading and in vitro release of paclitaxel
Cross-linked valerolactone copolymer implants with tailorable biodegradation, loading and in vitro release of paclitaxel
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NSTL
Elsevier
Implantable drug delivery systems, formed from degradable and non-degradable polymers, can offer several advantages over traditional dosage forms for sustained drug delivery. The majority of degradable implant systems developed to date are composed of poly(lactide-co-glycolide) (PLGA). However, PLGA-based systems are not suitable for the delivery of all drugs. Each drug is unique in terms of physico-chemical properties, and polymer-drug compatibility plays a significant role in determining a drug formulation's performance. In this study, two novel cross-linkable delta-valerolactone-based copolymers were synthesized and used to prepare crosslinked disc-shaped implants. The manipulation of the composition of the discs and conditions used during drug loading were found to influence various aspects of the delivery system performance including the degree of swelling, degradation, drug-loading and in vitro release. The polymeric discs resulted in no adverse effects following subcutaneous implantation in naive rats. These studies support further development of cross-linkable valerolactone matrices as implantable formulations for sustained drug delivery.
Paclitaxel (PTX)Polymeric drug deliveryImplantDegree of swellingCross-linkingLoading and releaseDegradation
Bufton, Jack、Jung, Sungmin、Evans, James C.、Bao, Zeqing、Aguiar, Dean、Allen, Christine
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Univ Toronto, Leslie Dan Fac Pharm, 144 Coll St, Toronto, ON M5S 3M2, Canada
JLabs Toronto, Pendant BioSci Inc, 661 Univ Ave,Suite 1300, Toronto, ON M5G 0B7, Canada
NSTL
Elsevier
