首页|Acrocalysterols A and B, two new steroids from endophytic fungus Acrocalymma sp

Acrocalysterols A and B, two new steroids from endophytic fungus Acrocalymma sp

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  • NSTL
  • Elsevier
? 2022 Phytochemical Society of EuropeTwo new steroids, named acrocalysterols A (1) and B (2), together with five known compounds were isolated and characterized from an endophytic fungus Acrocalymma sp., isolated from the tender stems of Sinomenium acutum. The structures of the isolated metabolites were identified based on UV, IR NMR (1D and 2D), HR-ESI-TOF-MS, single-crystal X-ray diffraction experiment using Cu Kα radiation and CD spectra associated with TD-DFT calculation. The bioassay showed that compound 2 displayed potent cytotoxicity against three cancer cell lines HeLa, HCC-1806, and RKO with IC50 values ranging from 18.37 to 19.64 μM.

Acrocalymma sp.CytotoxicityEndophytic fungusSinomenium acutumSteroid

Liu J.、Hu J.-Y.、Duan D.-Z.、Xiao J.、Wang X.-L.、Wu G.-W.、Yang T.、Fan P.-H.、Lin L.-B.

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Shaanxi Key Laboratory of Phytochemistry College of Chemistry and Chemical Engineering Baoji University of Arts and Sciences

College of Chemical Engineering Nanjing Forestry University

Department of Natural Product Chemistry Key Lab of Chemical Biology of Ministry of Education School of Pharmaceutical Sciences Shandong University

2022

10.1016/j.phytol.2022.02.003

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.48
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