首页|Night shift work and lymphoma: results from an Italian multicentre case-control study

Night shift work and lymphoma: results from an Italian multicentre case-control study

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  • NSTL
  • Bmj Publishing Group
Background Night shift work can disrupt circadian rhythm and cause chronic sleep deprivation， which might increase the risk of lymphoma through immunosuppression and oxidative stress。 Material and methods We investigated the association between night shift work and risk of lymphoma subtypes in 867 incident cases and 774 controls， who participated in a multicentre Italian study between 2011 and 2017。 Based on questionnaire information， occupational experts assessed the lifetime probability of night shift work， the total number of night shifts and years of night shift work among study participants。 OR and 95% CI for lymphoma and its major subtypes associated with night shift work was calculated with logistic regression， adjusting by age， gender， education， study area， marital status and family history of haemolymphatic cancer。 Results Ever working night shifts was associated with an increase in the risk of chronic lymphocytic leukaemia (CLL) (OR 1。9， 95% CI 1。14 to 3。32)， which was highest after a 15-34 years latency。 However， there was not a linear increase in risk by probability of exposure， years of night shift work， nor lifetime number of night shifts whether under rotating or permanent work schedules。 Risk of lymphoma overall， B cell lymphoma (BCL)， its major subtypes other than CLL， and other less prevalent BCL subtypes combined did not show an association。 Conclusions We found conflicting evidence of an association between night shift work and the risk of CLL。 We did not observe an association with other lymphoma subtypes。

hematologysleepretrospective studiesshift work scheduleoccupational healthRISKCANCERSLEEPMORTALITYEXPOSURECOHORTSYSTEM

Gambelunghe, Angela、Muzi, Giacomo、Ferri, Giovanni Maria、Vimercati, Luigi、Zanotti, Roberta、Scarpa, Aldo、Zucca, Mariagrazia、Latte, Gian Carlo、Angelucci, Emanuele、De Matteis, Sara、Puligheddu, Monica、Cocco, Pierluigi、Piro, Sara、Meloni, Federico、Montagna, Andrea、Pani, Michele、Pilia, Ilaria、Padoan, Marina、Miligi, Lucia、Magnani, Corrado

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Dept Med & Surg,Univ Perugia

Interdisciplinary Dept Med DIM,Univ Bari

Dept Haematol,Univ Verona

Dept Diagnost & Publ Hlth,Univ Verona

Dept Med Sci & Publ Hlth,Univ Cagliari

Dept Haematol,S Francesco Hosp

Dept Haematol,IST Natl Inst Canc Res

Canc Risk Factors & Lifestyle Epidemiol Unit,ISPRO Inst Prevent Res & Canc Network

Amedeo Avogadro Sch Med,Univ Piemonte Orientale

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2022

10.1136/oemed-2021-107845

Occupational and environmental medicine

Occupational and environmental medicine

SCI
ISSN：1351-0711
年,卷(期)：2022.79(7)
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