Abstract
Reverting the orientation of a functional group by exchanging molecular parts of it is an important scaffold hopping manipulation,as biologically active compounds and their analogs,which underwent such a transformation,are often similar in shape and physicochemical properties and therefore likely in their potency as well.This review will demonstrate,how the inversion of carboxamides,sulfonamides,carbamates,oximes,hydrazones,0,S-acetals,and ethers led to the discovery of highly active agrochemicals.
NSTL