首页|Structural, thermal, electronic, vibrational, magnetic, and cytotoxic properties of chloro(glycinato-N,O)(1,10-phenanthroline-N,N ')-copper(II) trihydrate coordination complex

Structural, thermal, electronic, vibrational, magnetic, and cytotoxic properties of chloro(glycinato-N,O)(1,10-phenanthroline-N,N ')-copper(II) trihydrate coordination complex

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  • NSTL
  • Elsevier
Chloro(glycinato-N,O)(1,10-phenanthroline-N,N ')-copper(II) trihydrate complex was synthesized through the slow evaporation method. The crystal's structural, thermal, magnetic, and vibrational properties were obtained by X-ray powder diffraction (XRPD), thermal analyses, magnetization, Raman, and Fourier-transform infrared (FT-IR) spectroscopy. XRPD results showed that the crystalline complex belongs to a monoclinic system (P21/n). Thermal analyses revealed that around 333 K, the material undergoes a thermodynamically irreversible process. Magnetic data showed a paramagnetic behavior with weak ferromagnetic interactions. Moreover, all the Ramanand infrared-active bands were assigned from computational calculations based on the density functional theory (DFT) to analyze intra-molecular vibrational modes. In addition, the cytotoxic assay on colorectal cancer cells was performed to evaluate the antitumor activity of this ternary compound. Therefore, the antineoplastic activity of [Cu(1,10-phenanthroline)(glycine)Cl]center dot 3H2O complex in HCT-116 cells was confirmed, showing a potent cytotoxic effect.

Metal-organic complex110-phenanthroline complexChemical and physical propertiesDFT calculationsAntitumor activityColorectal carcinomaMETAL-COMPLEXESCOPPER(II) COMPLEXESCRYSTAL-STRUCTURERAMAN-SPECTRADFTENERGYELECTRONEGATIVITYMONOHYDRATEDISEASESDESIGN

de Oliveira Neto, J. G.、Filho, J. G. Silva、Bittar, E. M.、Silva, L. M.、de Sousa, F. F.、Domingos, H. V.、Costa-Lotufo, L. V.、Reis, A. S.、dos Santos, A. O.

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Univ Fed Maranhao

Ctr Brasileiro Pesquisas Fis

Univ Sao Paulo

2022

10.1016/j.jinorgbio.2021.111658

Journal of Inorganic Biochemistry

Journal of Inorganic Biochemistry

ISTP
ISSN：0162-0134
年,卷(期)：2022.226
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