The Journal of surgical research.2022，Vol.2747.DOI:10.1016/j.jss.2021.12.040

The Effect of the Commonly Used Local Anesthetic on Bacterial Growth

Callahan, Zachary M. Roberts, Amity L. Christopher, Adrienne N. Gadomski, Stephen P. Kuchta, Kristine M. Costanzo, Caitlyn M. Phillips, Benjamin R. Isenberg, Gerald A. Goldstein, Scott D.
The Journal of surgical research.2022，Vol.2747.DOI:10.1016/j.jss.2021.12.040
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  • NSTL
  • Elsevier

The Effect of the Commonly Used Local Anesthetic on Bacterial Growth

Callahan, Zachary M. 1Roberts, Amity L. 2Christopher, Adrienne N. 1Gadomski, Stephen P. 1Kuchta, Kristine M. 3Costanzo, Caitlyn M. 1Phillips, Benjamin R. 1Isenberg, Gerald A. 1Goldstein, Scott D.1
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作者信息

  • 1. Dept Surg,Thomas Jefferson Univ
  • 2. Dept Lab Med,Hartford Healthcare
  • 3. Dept Biostat & Bioinformat,NorthShore Univ HealthSyst
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Abstract

Introduction: Liposomal bupivacaine (LB) has emerged as a superior form of local anesthetic across numerous surgical subspecialties. The purpose of this study is to evaluate the ex -vivo antimicrobial effects of LB in comparison with traditional local anesthetics. Methods: A standardized inoculum of bacteria commonly associated with surgical site infection was inoculated into a suspension of 1% lidocaine, 0.25% bupivacaine, Exparel (proprietary liposomally packaged 1.3% bupivacaine), and normal saline as a growth control. Results: In all five bacteria tested, the medium inoculated with traditional local anesthetics reduced growth to a greater degree than LB-inoculated plates. Both conventional local anesthetics reduced the growth of all bacteria when compared with the control with the exception of methicillin-susceptible Staphylococcus aureus growth in bupivacaine. LB-inoculated plates had equivalent growth to the control in all plates with the exception of Escherichia coli plates which demonstrated superior growth. Conclusions: The results of this simple ex-vivo model suggest that the liposomal packaging of bupivacaine may decrease this local anesthetic's innate antibacterial properties. (c) 2022 Elsevier Inc. All rights reserved.

Key words

Antimicrobial/Local anesthetic/Liposome/Bupivacaine/Surgical site infection/SURGICAL SITE INFECTIONS/ANTIMICROBIAL ACTIVITY/BUPIVACAINE/ANALGESIA/SURGERY/AGENTS

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出版年

2022
The Journal of surgical research.

The Journal of surgical research.

ISSN：0022-4804
参考文献量15
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