首页|Environmental exposures contribute to respiratory and allergic symptoms among women living in the banana growing regions of Costa Rica
Environmental exposures contribute to respiratory and allergic symptoms among women living in the banana growing regions of Costa Rica
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NSTL
Bmj Publishing Group
Objectives This research evaluates whether environmental exposures (pesticides and smoke) influence respiratory and allergic outcomes in women living in a tropical， agricultural environment。 Methods We used data from 266 mothers from the Infants' Environmental Health cohort study in Costa Rica。 We evaluated environmental exposures in women by measuring seven pesticide and two polycyclic aromatic hydrocarbons metabolites in urine samples。 We defined 'high exposure' as having a metabolite value in the top 75th percentile。 We collected survey data on respiratory and allergic outcomes in mothers as well as on pesticides and other environmental exposures。 Using logistic regression models adjusted for obesity， we assessed the associations of pesticide exposure with multiple outcomes (wheeze， doctor-diagnosed asthma， high (>= 2) asthma score based on symptoms， rhinitis， eczema and itchy rash)。 Results Current pesticide use in the home was positively associated with diagnosed asthma (OR=1。99 (95% CI=1。05 to 3。87))。 High urinary levels of 5-hydroxythiabendazole (thiabendazole metabolite) and living in a neighbourhood with frequent smoke from waste burning were associated with a high asthma score (OR=1。84 (95%CI=1。05 to 3。25) and OR=2。31 (95%CI=1。11 to 5。16)， respectively)。 Women who worked in agriculture had a significantly lower prevalence of rhinitis (0。19 (0。01 to 0。93))， but were more likely to report eczema (OR=2。54 (95%CI=1。33 to 4。89)) and an itchy rash (OR=3。17 (95%CI=1。24 to 7。73))。 Conclusions While limited by sample size， these findings suggest that environmental exposure to both pesticides and smoke may impact respiratory and skin-related allergic outcomes in women。
Alhanti, Brooke、de Joode, Berna van Wendel、Martinez, Manuel Soto、Mora, Ana M.、Gamboa, Leonel Cordoba、Reich, Brian、Lindh, Christian H.、Lepiz, Marcela Quiros、Hoppin, Jane A.
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Duke Clin Res Inst,Duke Univ
Cent Amer Inst Studies Tox Subst IRET,Univ Nacl Costa Rica
Resp Dept,Hosp Nacl Ninos Dr Carlos Saenz Herrera
Ctr Human Hlth & Environm,North Carolina State Univ
NSTL
Bmj Publishing Group
