Bioactive cytochalasans from the fungus Arthrinium arundinis DJ-13
Shu, Yan 1Wang, Jia-Peng 1Li, Bing-Xian 1Gan, Jun-Li 1Ding, Hao 1Liu, Rui 1Cai, Le 1Zhong-Tao Ding1
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作者信息
1. Yunnan Univ
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Abstract
The investigation of the metabolites from Arthrinium arundinis DJ-13 grown in solid medium revealed six undescribed cytochalasans, arundisins A-F and twelve known compounds. Their structures were initially investigated in detail by spectroscopic analyses and were further confirmed by X-crystallography and ECD experiments. In the in vitro bioassays, arundisins A and B showed cytotoxic activity against the MCF-7 breast cancer cell line with IC50 values of 18.82 +/- 0.36 and 15.20 +/- 0.42 mu M, respectively. Arundisin F exhibited potent antibacterial activity against Escherichia coli with MIC of 8.00 mu g/mL (kanamycin, 2.00 mu g/mL), and arundisin D displayed gently antibacterial activity against Candida albicans with MIC of 32.00 mu g/mL (Nystatin, 1.00 mu g/mL).
NSTL
Elsevier