Tetrahedron letters2022，Vol.994.DOI:10.1016/j.tetlet.2022.153822

Copper-catalyzed oxidative cross-dehydrogenative coupling (CDC) reaction of alcohols with secondary phosphine oxides

Hua, Yingxiang Lin, Yanchao Chen, Wenyi Ye, Liyi Yin, Yingwu Gao, Yuxing Tu, Song
Tetrahedron letters2022，Vol.994.DOI:10.1016/j.tetlet.2022.153822
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  • NSTL
  • Elsevier

Copper-catalyzed oxidative cross-dehydrogenative coupling (CDC) reaction of alcohols with secondary phosphine oxides

Hua, Yingxiang 1Lin, Yanchao 1Chen, Wenyi 1Ye, Liyi 1Yin, Yingwu 1Gao, Yuxing 1Tu, Song1
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作者信息

  • 1. Xiamen Univ
  • 折叠

Abstract

A copper-catalyzed oxidative cross-dehydrogenative coupling (CDC) strategy of secondary phosphine oxides and alcohols for the synthesis of various phosphinate esters was proposed. Under the mild reaction conditions (CuCl2 center dot 2H(2)O/K2S2O8, at room temperature for 3-12 h under air), a variety of substrates were well-tolerated and afforded the desirable compounds in moderate to excellent yields. (C) 2022 Elsevier Ltd. All rights reserved.

Key words

P-O bond formation/Phosphinate esters/Secondary phosphine oxides/Alcohols/AMINES/BOND/PHOSPHORYLATION/PHOSPHATES/FACILE

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
被引量5
参考文献量39
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