首页|Adipose derived stem cells to construct parathyroid organoid for hypoparathyroidism
Adipose derived stem cells to construct parathyroid organoid for hypoparathyroidism
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NSTL
Elsevier
Hypoparathyroidism is one of the most common postoperative complications of thyroid surgery， and organoid transplantation is a frontier field expected to treat hypoparathyroidism。 Organoids are three-dimensional cell aggregates derived from embryonic stem cells， pluripotent stem cells， or tissue precursor cells， possessing similar structures and functions to organs。 Thus they can replace diseased organs to play a role。 Adipose-derived stem cells (ASCs) are a population of postnatal stem cells residing in the fat tissue， capable of differentiating into parathyroid-like cells with parathyroid hormone secretion function。 Additionally， we have prepared cartilaginous organoids by intelligent porous hydrogel and differentiated ASCs via ?bottom-up? strategy in vitro。 Therefore， we speculate that parathyroid organoids can be achieved by the biomaterial-assisted assembly of differentiated adipose stem cells and it is a promising treatment for hypoparathyroidism。
NSTL
Elsevier
