首页|Population Pharmacokinetics of Intraventricular Vancomycin in Neonatal Ventriculitis, A Preterm Pilot Study

Population Pharmacokinetics of Intraventricular Vancomycin in Neonatal Ventriculitis, A Preterm Pilot Study

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  • NSTL
  • Elsevier
Aim: Intraventricular vancomycin is an effective treatment for neonatal ventriculitis, as the cerebrospinal fluid (CSF) vancomycin levels reach adequate concentrations to achieve microbiological cure. There is no robust data on intraventricular vancomycin pharmacokinetics in the preterm population. This pilot population pharmacokinetic modelling study examines the pharmacokinetic behaviour of intraventricular vancomycin in the preterm population of < 28 weeks gestation, to inform the feasibility of future prospective studies.

intraventricular vancomycinneonatal ventriculitispreterm pharmacokineticsNONMEM modelling

Parasuraman, Jaya Madhura、Kloprogge, Frank、Standing, Joseph Frank、Albur, Mahableshwar、Heep, Axel

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Southmead Hosp, Neonatal Intens Care Unit, Southmead Rd, Bristol BS10 5NB, Avon, England

UCL, Inst Global Hlth, 30 Guilford St, London WC1N 1EH, England

UCL, Inst Child Hlth, Infect Inflammat & Rheumatol Sect, 30 Guilford St, London WC1N 1EH, England

Southmead Hosp, Dept Med Microbiol, Southmead Rd, Bristol BS10 5NB, Avon, England

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2021

10.1016/j.ejps.2020.105643

European journal of pharmaceutical sciences

European journal of pharmaceutical sciences

ISTP
ISSN：0928-0987
年,卷(期)：2021.158
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