SNAr reactions of 5-bromo-2-chloro-4-fluoro-3-iodopyridine and its 3-substituted analogs
Porter, Gerard 1Saulnier, Mark 1Wu, Yong-Jin1
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作者信息
1. Small Mol Drug Discovery
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Abstract
We have previously demonstrated that 5-bromo-2-chloro-4-fluoro-3-iodopyridine (6) can serve as a versatile intermediate to penta-substituted pyridines. This work describes regioselective SNAr reactions of 6 and its 3-substituted analogs with a variety of nucleophiles to deliver highly functionalized pyridines as valuable building blocks in medicinal chemistry and drug design. (C) 2022 Elsevier Ltd. All rights reserved.
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Elsevier