首页|Pyridine salts and aliphatic chains regulating membrane-targeted ratiometric fluorescence probe for detection of SO2 in living cells
Pyridine salts and aliphatic chains regulating membrane-targeted ratiometric fluorescence probe for detection of SO2 in living cells
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Cell membrane is the barrier between cell and environment,which is an important structural basis for maintaining cell environment stability and regulating cell normal life activities.There are important active molecules in the cell membrane,so it is of great biological and medical significance to explore the physiological functions of active molecules in the cell membrane.In this work,probe that co-regulating cell membrane targeting by pyridine salts and lipid chains was developed.In this probe,using pyridine salt as receptor and coumarin derivatives as donor constructed a ratiometric fluorescent probe MCP based on ICT for specific recognition of SO2 derivatives.MCP was selected the cyanide group as the SO_3~(2-)response site,and the introduction of pyridine propyl,which regulates hydrophobicity,so as to achieve efficient targeting of cell membranes.MCP showed high sensitivity and selectivity for SO_3~(2-).Moreover,MCP showed a fast response time(30 s)and red fluorescence emission wavelength(645 nm).In addition,MCP can successfully applying to detect endogenous SO2 on the cell membranes.
Department of Chemistry and Chemical Engineering,Lvliang University,Lishi,033001,China
Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education,Institute of Molecular Science,Shanxi University,Taiyuan,030006,China
Research Institute of Applied Chemistry,Shanxi University,Taiyuan,030006,China
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