Abstract The Golgi apparatus is a membrane‐bound organelle that functions as a central role in the secretory pathway. Since the discovery of the Golgi apparatus, its structure and function have attracted ever‐increasing attention from researchers. Recently, it has been demonstrated that metal ions are necessary for the Golgi apparatus to maintain its proper structure and functions. Given that metal ions play an important role in various biological processes, their abnormal homeostasis is related to many diseases. Therefore, in this paper, we reviewed the uptake and release mechanisms of the Golgi apparatus Ca2+, Cu, and Zn2+. Furthermore, we describe the diseases associated with Golgi apparatus Ca2+, Cu, and Zn2+ imbalance.
Ca2+CuGolgi apparatusmetal ionsZn2+
Jiayin Gao、Anbo Gao、Hong Zhou、Linxi Chen
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Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan
Department of Radiology of the First Affiliated Hospital of University of South China
NSTL
Wiley
