首页|Meroterpenoids with a large conjugated system from Ganoderma lucidum and their inhibitory activities against renal fibrosis

Meroterpenoids with a large conjugated system from Ganoderma lucidum and their inhibitory activities against renal fibrosis

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  • NSTL
  • Elsevier
? 2022Baoslingzhines A–E (1–5), five new meroterpenoids were isolated from the fruiting bodies of Ganoderma lucidum. The structures including their absolute configurations were characterized by using spectroscopic and computational methods. Compound 1 is a novel trinormeroterpenoid featuring the presence of an unusual dihydronaphthalene representing an unprecedented meroterpenoid skeleton. Compounds 2–4 are mononormeroterpenoids characteristic of a large conjugated system. Among them, racemic 3 and 4 were separated by HPLC on chiral phase. Biological evaluation toward kidney fibrosis found that compounds 2 and (+)-3 could inhibit the expression of fibronectin and collagen I dose dependently in TGF-β1-induced rat kidney proximal tubular cells (NRK-52e). Additionally, (+)-3 could also down regulate ɑ-SMA in a concentration dependent manner. Further investigation showed that 2 could inhibit Smad2 phosphorylation.

Ganoderma lucidumLarge conjugated systemMeroterpenoidsRenal fibrosis

Wang Y.-X.、Huang L.-S.-X.、Peng Y.-L.、Lv Q.、Cheng Y.-X.、Qiu B.

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Key Laboratory of Chemistry in Ethnic Medicinal Resources State Ethnic Affairs Commission & Ministry of Education School of Ethnic Medicine Yunnan Minzu University

Institute for Inheritance-Based Innovation of Chinese Medicine School of Pharmaceutical Sciences Health Science Center Shenzhen University

Yunnan University of Chinese Medicine

2022

10.1016/j.fitote.2022.105257

Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
年,卷(期)：2022.161
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