A highly stereoselective asymmetric Henry reaction using a double fluorous-tagged Co-salen complex was conducted. The introduction of two fluorous tags into the Co-salen complex was found to be more effective in terms of improving stereoselectivity than the introduction of a strong electron-withdrawing nitro group into the same position of the salen ligand. The observed stereoselectivity was significantly higher than that when using a Jacobsen-type Co-salen complex bearing the same asymmetric source. (c) 2022 Elsevier Ltd. All rights reserved.
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