Natural product research2022，Vol.36Issue(4/6) ：5.DOI:10.1080/14786419.2020.1862832

Phytochemical characterization, genotoxicity, cytotoxicity, and antimicrobial activity of Gautheria procumbens essential oil

Camila Marina,Verdi Vanessa Schopf,Machado Alencar Kolinsk,Machado Bruna,Klein Pauline Cordenonsi,Bonez Eduardo Nascimento Correa,de Andrade Grazielle,Rossi Marli Matiko,Campos Roger,Wagner Michele Rorato,Sagrillo Roberto Christ Vianna,Santos
Natural product research2022，Vol.36Issue(4/6) ：5.DOI:10.1080/14786419.2020.1862832
✕
  • NSTL
  • Taylor & Francis

Phytochemical characterization, genotoxicity, cytotoxicity, and antimicrobial activity of Gautheria procumbens essential oil

Camila Marina,Verdi 1Vanessa Schopf,Machado 1Alencar Kolinsk,Machado 2Bruna,Klein 3Pauline Cordenonsi,Bonez 1Eduardo Nascimento Correa,de Andrade 4Grazielle,Rossi 5Marli Matiko,Campos 5Roger,Wagner 3Michele Rorato,Sagrillo 2Roberto Christ Vianna,Santos1
扫码查看

作者信息

  • 1. Laboratory of Oral Microbiology Research (LAPEMICRO), Federal University of Santa Maria
  • 2. Laboratory of Cell Culture, Graduate Program in Nanosciences –Franciscana University
  • 3. Integrated Center for Laboratory Analysis Development (NIDAL), Department of Food Technology and
  • 4. Center of Health Science – Medicine – UFSM
  • 5. Laboratory of Mycobacteriology (LABIMYCO), Federal University of Santa Maria
  • 折叠

Abstract

Abstract This study investigated the chemical constituents of Gaultheria procumbens essential oil and is the first to relate cytogenotoxicity with oxidative metabolism and antimicrobial activity. Chromatographic analysis of the essential oil showed methyl salicylate (99.96%) and linalool (0.04%) as the major compounds. The essential oil showed no signs of cytogenotoxicity at different concentrations (1.82 to 58.34?mg mL?1). Furthermore, G. procumbens essential oil and methyl salicylate were used to evaluate the minimal inhibitory concentrations (MIC) and minimal microbicidal concentrations (MMC). The results showed efficacy against several microorganisms, including Aeromonas caviae, Candida albicans, and Mycobacterium fortuitum with MIC values ranging from 1.82 to 3.64?mg mL?1 and MMC values ranging from 3.64 to 12.67?mg mL?1, which were confirmed by time-kill kinetics. Based on our results, the essential oil is a promising alternative to developing future formulations to treat infections caused by microorganisms.

Key words

Toxicity/PBMCs/time-kill/MIC/methyl salicylate/microorganism/mycobacterium

引用本文复制引用

出版年

2022
Natural product research

Natural product research

SCI
ISSN：1478-6419
被引量2
参考文献量16
段落导航相关论文